Your Gut Could Hold the Key to Treating Arthritis – Yale Study Reveals

🦴 Osteoarthritis isn’t just "wear and tear" anymore! New research in Science shows your gut bacteria and bile acids play a major role in joint damage.

The Breakthrough:
✔ Gut-Joint Connection: Harmful bacteria (C. bolteae) disrupt bile acids → speeding up cartilage breakdown
✔ Good Bile Acid (GUDCA) slows arthritis progression
✔ Diabetes Drugs (like Ozempic) may help – GLP-1 protects joints

💊 Hope for New Treatments:

  • UDCA (an existing liver drug) reduced joint inflammation in trials

  • Future therapies could target gut bacteria to stop arthritis early

"This changes everything – arthritis isn’t just mechanical, it’s metabolic," says Yale’s Dr. Chuan-Ju Liu.

#ArthritisResearch #GutHealth #MedicalBreakthrough 


Reference:

Yang Y, Hao C, Jiao T, et al. Osteoarthritis treatment via the GLP-1–mediated gut-joint axis targets intestinal FXR signaling. Sci. 2025;388(6742):eadt0548. doi: 10.1126/science.adt0548

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